Morpholine CAS NO.110-91-8
|Terms of Trade:||FOB,CFR,CIF|
|Delivery Time:||10 Days|
|Productivity:||50,000tons per year|
|Place of Origin:||CHINA|
|Supply Ability:||30,000tons per year|
Model No.: 110-91-8
|Morpholine Basic information|
|Product Features Chemical properties Uses metal corrosion inhibitors rubber vulcanization acceleratorquantitative analysis Production method Hazards & Safety Information|
|Synonyms:||Doxapram Impurity 2 (Morpholine);Drewamine;morpholine,aqueousmixture,[corrosivelabel];morpholine,aqueousmixture,[flammableliquidlabel];NA 2054;p-Isoxazine, tetrahydro-;Tetrahydro-1,4-isoxazine;Tetrahydro-1,4-oxadine|
|Product Categories:||-;Organic Chemicals;BasesChemical Synthesis;Organic Bases;Supported Reagents;Supported Synthesis;Synthetic Reagents;Thiophenes;ACS Grade;Building Blocks;C4 to C10;Chemical Synthesis;Essential Chemicals;Heterocyclic Building Blocks;Inorganic Salts;Morpholines/Thiomorpholines;Research Essentials;Solutions and Reagents;Organic solvents|
|Morpholine Chemical Properties|
|Melting point||-5 °C|
|Boiling point|| 129 °C(lit.) |
|density|| 1.000 g/mL at 20 °C |
|vapor density|| 3 (vs air) |
|vapor pressure|| 31 mm Hg ( 38 °C) |
|refractive index|| n20/D 1.454(lit.) |
|Fp|| 96 °F |
|storage temp.||Store at R.T.|
|Exposure limits||TLV-TWA 20 ppm (~70 mg/m3) (ACGIH, MSHA, and OSHA); STEL skin 30 ppm (ACGIH); IDLH 8000 ppm.|
|Stability:||Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides. Hygroscopic.|
|CAS DataBase Reference||110-91-8(CAS DataBase Reference)|
|NIST Chemistry Reference||Morpholine(110-91-8)|
|EPA Substance Registry System||Morpholine(110-91-8)|
|RIDADR|| UN 2054 8/PG 1 |
|WGK Germany|| 3 |
|RTECS|| QD6475000 |
|Autoignition Temperature||590 °F|
|HS Code||2934 99 90|
|Hazardous Substances Data||110-91-8(Hazardous Substances Data)|
|Toxicity||LD50 orally in female rats: 1.05 g/kg (Smyth)|
|Morpholine Usage And Synthesis|
|Product Features|| Morpholine, also known as 1, 4-oxazepine and diethylenimine oxide, is a kind of colorless alkaline oily liquid. It smells of ammonia and has hygroscopicity. Morpholine could evaporate with water vapor and miscible with water. It is Soluble in acetone, benzene, ether, pentane, methanol, ethanol, carbon tetrachloride, propylene glycol and other organic solvents. Morpholine Vapor could form an explosive mixture with air and the explosion limit is 1.8% to 15.2% (volume fraction). Morpholine is a secondary amine, and at the same time it has the property of inorganic acid and organic acid, so that it can generate salt and amide. |
Morpholine contains secondary amine groups and it has all the typical reaction characteristics of the secondary amine groups. It can react with inorganic acid to form a salt, and also can react with organic acid to form salt or amide. Morpholine can carry out alkylation reactions and it also carry out ketone reaction or Willgerodt reaction with ethylene oxide. Because of the unique chemical properties of morpholine, it has become one of the important petrochemical products with important commercial application. It can be applied to produce rubber vulcanization accelerators such as NOBS, DTOS and MDS. And it is also applied to produce anti-corrosives, anti-corrosion agents, detergents, detergents, analgesics, local anesthetics, sedatives, respiratory and vascular stimulants, surfactants, optical bleach, fruit preservatives, and textile dyeing auxiliaries. Morpholine also has a wide range of applications in the field of rubber, pharmaceuticals, pesticides, dyes, coatings and other industries. In medication it could be applied in the production of morpholine guanidine, virus Ling, ibuprofen, cough must, naproxen, dichloroaniline, sodium phenylacetate and other important drugs.
The two main production method of morpholine are DEA method (diethanolamine method) and DEA method (diethylene glycol method)
It is noteworthy that new polymer monomer acrylic morpholine has obtained a rapid development in recent years. Acrylic acid morpholine could be produced from the reaction between acrylic acid and morpholine. And acrylic acid morpholine is a kind of water-soluble monomer, and it is still water-soluble after the polymerization. So it could be applied for the modification of aqueous polymers. Besides, acrylic morpholine is widely used as a reactive diluent for UV curable resins. With the deepening of applied research, many new specific uses have been developed and it becomes polymer monomer with rapid development.
Figure 1 for the morpholine structure
|Chemical properties||It is colorless water-absorbing oily liquid and it smells ammonia. It is soluble in water and methanol, ethanol, benzene, acetone, ether, ethylene glycol and other commonly used solvents.|
|Uses|| (1) For medicine, it used as the raw materials for rubber accelerator and fluorescent whitening agent. |
(2) Morpholine is the intermediates of fungicide dimethomorph and flumorpholine and organophosphate insecticide phosalphos.
(3) Morpholine is Mainly used for the production of rubber vulcanization accelerator, but also for surfactant, textile auxiliaries, pharmaceuticals, pesticide synthesis. (4) Morpholine also used as a catalyst for polymerization of butadiene, corrosion inhibitors, optical bleach, the goods are dyes, resins, wax, early glue, casein and other solvents. At present, the total production of morpholine in the world is 3-4 million t/a.
(5) Morpholine salts are also widely used. Morpholine salts like morpholine hydrochloride (10024-89-2) are the organic synthesis of intermediates. Morpholine fatty acid salt can be used as the coating agent of fruits or vegetables epidermal coating agent, and it could inhibit the base respiration and prevent the epidermis from evaporation of water and epidermal atrophy.
(6) Morpholine is the main raw materials of accelerator NOBS. for analysis reagents and resins, wax, shellac and other solvents, used in the production of sodium sulfate. Water glass and ultramarine. Also used in the manufacture of glass. Paper. Detergent. Soap. Dye. Synthetic fiber. Tanning. Medicine and ceramics industries. Analysis reagents, such as nitrogen determination, dehydrating agent.
(7) Morpholine is used for the analysis of reagents and resins, wax, casein, shellac and a variety of solvents solvent.
(8) Morpholine could produce salt after reacting with inorganic acid, and it also could produce salt or amide after reacting with organic acid. It also can be alkylated, and it also could come up a ketone reaction or Willgerodt reaction with ethylene oxide.
|metal corrosion inhibitors||As a kind of metal corrosion inhibitor, Morpholine is mainly applied for the anti-corrosion of iron, copper, zinc, lead and other metals. It remains at its starting stage in China, but outside the country, a considerable proportion of Morpholine are used as a kind of anti-rust agent for metal gas to prevent the metal corrosion caused by atmosphere and it has been widely used in the field of mechanical instruments, automobiles, medical equipment and others. The metal atmospheric rust inhibitor used earlier such as dicyclohexylamine nitrite and cyclohexylamine do harm to the human body and they are more environmentally toxic. Instead, morpholine as a metal gas-liquid corrosion inhibitor, it has the advantages of low toxicity, so the foreground is prosperous.|
|rubber vulcanization accelerator|| Before 1990's, in Europe, the United States, Japan and other developed areas, the consumption of rubber vulcanization accelerator accounted for more than 50% of the total demand for morpholine. At present, more than 30% consumption of rubber vulcanization accelerator is used for NOBS. |
In recent years, the toxicity issue of the harmful nitrosamines in the accelerator which produced during rubber processing is driving more attention internationally. A number of restrictive laws and regulations are introduced all around the world. For example, in Germany as early as 1982, the law about the regulations issued nitrosamine content control was established. The United States, Japan, France, the United Kingdom actively developed new vulcanization accelerator which don`t produce nitrosamine, and they have stopped using nitrosamine which will produce vulcanization accelerator. Therefore, the consumption of morpholine in foreign countries has decreased with banning of the accelerator NOBS year by year. In China however, we have no corresponding regulations prohibited about banning accelerator NOBS. But China has joined the WTO, due to a large number of foreign enter and high requirement about additives localization, it requires more environmental protection in China's rubber vulcanization accelerator. Using non-toxic promoter and replacing NOBS becomes the general trend. China's demand for NOBS is significantly reduced in recent years. China will no longer use basic decomposition of nitrosamine secondary amine accelerator. As the main substitute of NOBS, NS (N-tert-butyl-2-benzothiazole sulfonamide), which does not produce nitrosamines, has a large production capacity. In 2005, the output was 14,000 tons and it is 10.1%, of the total amount. So there was good development momentum.
|quantitative analysis|| Get 4 parts of methanol solution with 0.1% of bromocresol green and 1 part of 0.1% aqueous solution with 0.1% of methyl red sodium salt. Mix them and put aside to use as a mixed indicator later. |
Get 50ml water in 250ml flask, add 0.4ml mixed indicator, drop 0.1moI/L hydrochloric acid, and wait for the color to turn green. Accurately weighs the sample 1.4~1.6g, add the flask and mix it. Use 0.5mol/L hydrochloric acid titration and wait for the color to turn green. Per ml, 0.5mol/L hydrochloric acid is equivalent to 43.56mg C4H9NO.
|Production method|| (1) Morpholine could be produced by diethanolamine dehydration cyclization derived from sulfuric acid. Add diethanolamine to the water reaction Pot and drop sulfuric acid in the temperature of 60 ℃, then when the temperature heat at 185-195 ℃, incubate it for 30min. Cool it to under 60℃ and drop sodium hydroxide solution to pH = 11. The next steeps are cooling, filtering, filtrating distillation, collecting the following fractions below 130℃. The content of spermine is suppose to reach more than 99.5%. The method is easy to obtain raw materials, so it has become the main method of producing morpholine in the world. Morpholine also could be produced in the catalytic reaction between dioxane and ammonia gas. |
(2) The preparation method is that we could get Morpholine from the presence of sulfuric acid dehydration cyclization diethanolamine In the presence of sulfuric acid ; then add diethanolamine into the reaction Kettle and add H2SO4 at a temperature of below 6 °C, then heat it to 185-195 °C for 30 minutes, cool to 60 °C. Drop NaOH solution to pH = 11, and the last two steeps is cooling and filtrating. Morpholine could be collected from the fraction below 130 °C.
We can also get morpholine from the reaction between diethylene glycol and ammonia in the presence of catalyst and pressure. The method is easy to obtain raw materials, thus it is the main method of producing morpholine around the world.
|Hazards & Safety Information|| category: Flammable liquids |
toxicity grading: Poisoning
acute toxicity: Oral-rat LD 50: 1050 mg/kg; oral-mouse LD 50: 525 mg/kg
Stimulating data: Skin-rabbit 995 mg/24 h severe; eye –rabbit 2 mg severe.
hazardous characteristic of explosive: Will cause explosion when it mixes with steam and air
hazardous characteristic of flammability: Flammable; combustion produces toxic chloride gas
transportation and storing properties: Store it in low temperature, dry and ventilated environment. Prevent from fire, friction,spark and Separated from oxidant
extinguishant: Water spray, dry chemical powder, foam or carbon dioxide
occupational standards: TLV-TWA 70 mg/m3 STEL 105 mg/m3
|Morpholine Preparation Products And Raw materials|
Jinan Forever Chemical Co., Ltd.
Jinan Forever Chemical Co., Ltd is a collection research and development, the trade to a body complex economic entity. By specialized management industrial chemicals primarily, AC blowing agent, Hydrazine Hydrate, Ferric Chloride Anhy, 2-aminophenol, Fluorescent brightener, Phosphorous acid, Pyridine, Sodium Carbonate and so on fine chemical product ability. Our products have obtained the ISO9001 international quality system authentication.
In the last few years, repling on the high-quality request, company`s product sale is extremely widespread. The year turnover continues to rise. The company is basing the domestic market development, at the same time it is also developing actively the international market and has already obtained the good effect. Now our company 30% products sell to the foreign market and we have obtained the oversea customers` consistent high praise and favour.
For company`s further development, the company leaders seek variously the long-term cooperation unit and have already established the good cooperation relations with the many domestic large-scale chemical companies, expanding own management scope and meeting the general customers` different demand. The company observes [the quality is excellent and the price is cheap" objective, consummation service attitude and first-class market management pattern. Thus we have won the general customers` trust. Our company expect to obtain the domestic and foreign colleagues` support vigorously in the next development. The company is willing sincerely to cooperate with the domestic and foreign merchants, communal development.
- Company Name: Jinan Forever Chemical Co., Ltd.
- Representative: Ma Guoguang
- Product/Service: Hydrazine Hydrate , 2-Aminophenol , Ferric Chloride Anhydrous , AC Blowing Agent , APIs , Brightening Agent
- Capital (Million US $): US$1 Million
- Year Established: 2005
- Total Annual Sales Volume (Million US $): US$1 Million - US$2.5 Million
- Export Percentage: 21% - 30%
- Total Annual Purchase Volume (Million US $): US$1 Million - US$2.5 Million
- No. of Production Lines: 5
- No. of R&D Staff: 11 -20 People
- No. of QC Staff: 21 -30 People
- OEM Services Provided: yes
- Factory Size (Sq.meters): 3,000-5,000 square meters
- Factory Location: Ningxia province, China
- Contact Person: Ms. Chloe Feng
- Tel: 86-152-88875230
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